Reactive carbonyls and oxidative stress: potential for therapeutic intervention

Pharmacol Ther. 2007 Jul;115(1):13-24. doi: 10.1016/j.pharmthera.2007.03.015. Epub 2007 May 8.


Reactive aldehydes and ketones are produced as a result of oxidative stress in several disease processes. Considerable evidence is now accumulating that these reactive carbonyl products are also involved in the progression of diseases, including neurodegenerative disorders, diabetes, atherosclerosis, diabetic complications, reperfusion after ischemic injury, hypertension, and inflammation. To counter carbonyl stress, cells possess enzymes that can decrease aldehyde load. These enzymes include aldehyde dehydrogenases (ALDH), aldo-keto reductases (AKR), carbonyl reductase (CBR), and glutathione S-transferases (GST). Some of these enzymes are inducible by chemoprotective compounds via Nrf2/ARE- or AhR/XRE-dependent mechanisms. This review describes the metabolism of reactive carbonyls and discusses the potential for manipulating levels of carbonyl-metabolizing enzymes through chemical intervention.

Publication types

  • Review

MeSH terms

  • Aldehydes / antagonists & inhibitors
  • Aldehydes / metabolism
  • Animals
  • Enzymes / metabolism
  • Free Radical Scavengers / pharmacology
  • Free Radical Scavengers / therapeutic use*
  • Free Radicals / antagonists & inhibitors*
  • Free Radicals / metabolism*
  • Humans
  • Ketones / antagonists & inhibitors
  • Ketones / metabolism
  • Oxidative Stress / physiology*


  • Aldehydes
  • Enzymes
  • Free Radical Scavengers
  • Free Radicals
  • Ketones