Effect of subinhibitory concentration of some established and experimental antifungal compounds on the germ tube formation in Candida albicans

Folia Microbiol (Praha). 2007;52(1):39-43. doi: 10.1007/BF02932136.

Abstract

The influence of subinhibitory concentrations of six established and 19 newly synthesized antifungal compounds on the dimorphic transition of three C. albicans strains was evaluated in the filamentation-inducing medium. Amphotericin B was found to produce almost complete inhibition in the germination at a concentration of 1/10 of the corresponding MIC and partial inhibition at a concentration as low as MIC/50. Flucytosine and four azole derivatives were proven ineffective. From the newly synthesized drugs, the incrustoporin derivative LNO6-22, two phenylguanidine derivatives (PG15, PG45), and four thiosalicylanilide derivatives, in particular, showed results comparable to those of amphotericin B, with a high inhibition of germ tube formation at concentrations of MIC/10. In general, concentrations of MIC/50 had no visible effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / chemical synthesis
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / pharmacology
  • Amphotericin B / pharmacology
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Candida albicans / growth & development*
  • Dose-Response Relationship, Drug
  • Guanidines / chemical synthesis
  • Guanidines / chemistry
  • Guanidines / pharmacology
  • Microbial Sensitivity Tests / methods
  • Microbial Sensitivity Tests / standards
  • Morphogenesis / drug effects*
  • Salicylates / chemical synthesis
  • Salicylates / chemistry
  • Salicylates / pharmacology
  • Sulfhydryl Compounds / chemical synthesis
  • Sulfhydryl Compounds / chemistry
  • Sulfhydryl Compounds / pharmacology

Substances

  • Antifungal Agents
  • Guanidines
  • Salicylates
  • Sulfhydryl Compounds
  • incrustoporin
  • phenylguanidine
  • Amphotericin B
  • thiosalicylic acid
  • 4-Butyrolactone