Abstract
The influence of subinhibitory concentrations of six established and 19 newly synthesized antifungal compounds on the dimorphic transition of three C. albicans strains was evaluated in the filamentation-inducing medium. Amphotericin B was found to produce almost complete inhibition in the germination at a concentration of 1/10 of the corresponding MIC and partial inhibition at a concentration as low as MIC/50. Flucytosine and four azole derivatives were proven ineffective. From the newly synthesized drugs, the incrustoporin derivative LNO6-22, two phenylguanidine derivatives (PG15, PG45), and four thiosalicylanilide derivatives, in particular, showed results comparable to those of amphotericin B, with a high inhibition of germ tube formation at concentrations of MIC/10. In general, concentrations of MIC/50 had no visible effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / chemical synthesis
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4-Butyrolactone / chemistry
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4-Butyrolactone / pharmacology
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Amphotericin B / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects*
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Candida albicans / growth & development*
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Dose-Response Relationship, Drug
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Guanidines / chemical synthesis
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Guanidines / chemistry
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Guanidines / pharmacology
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Microbial Sensitivity Tests / methods
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Microbial Sensitivity Tests / standards
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Morphogenesis / drug effects*
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Salicylates / chemical synthesis
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Salicylates / chemistry
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Salicylates / pharmacology
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Sulfhydryl Compounds / chemical synthesis
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Sulfhydryl Compounds / chemistry
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Sulfhydryl Compounds / pharmacology
Substances
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Antifungal Agents
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Guanidines
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Salicylates
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Sulfhydryl Compounds
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incrustoporin
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phenylguanidine
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Amphotericin B
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thiosalicylic acid
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4-Butyrolactone