How does chondroitinase promote functional recovery in the damaged CNS?

Exp Neurol. 2007 Aug;206(2):159-71. doi: 10.1016/j.expneurol.2007.05.001. Epub 2007 May 8.


A number of recent studies have established that the bacterial enzyme chondroitinase ABC promotes functional recovery in the injured CNS. The issue of how it works is rarely addressed, however. The effects of the enzyme are presumed to be due to the degradation of inhibitory chondroitin sulphate GAG chains. Here we review what is known about the composition, structure and distribution of the extracellular matrix in the CNS, and how it changes in response to injury. We summarize the data pertaining to the ability of chondroitinase to promote functional recovery, both in the context of axon regeneration and the reactivation of plasticity. We also present preliminary data on the persistence of the effects of the enzyme in vivo, and its hyaluronan-degrading activity in CNS homogenates in vitro. We then consider precisely how the enzyme might influence functional recovery in the CNS. The ability of chondroitinase to degrade hyaluronan is likely to result in greater matrix disruption than the degradation of chondroitin sulphate alone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Central Nervous System / drug effects*
  • Central Nervous System / injuries*
  • Central Nervous System / metabolism
  • Chondroitin ABC Lyase / pharmacology*
  • Chondroitin ABC Lyase / therapeutic use
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism
  • Gliosis / drug therapy
  • Gliosis / physiopathology
  • Gliosis / prevention & control
  • Growth Cones / drug effects
  • Growth Cones / metabolism
  • Humans
  • Hyaluronic Acid / metabolism
  • Nerve Regeneration / drug effects*
  • Nerve Regeneration / physiology
  • Neuronal Plasticity / drug effects*
  • Neuronal Plasticity / physiology
  • Recovery of Function / drug effects*
  • Recovery of Function / physiology


  • Hyaluronic Acid
  • Chondroitin ABC Lyase