Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Cell Death Differ. 2007 Sep;14(9):1711-3. doi: 10.1038/sj.cdd.4402178. Epub 2007 Jun 15.
No abstract available

Publication types

  • Letter

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Apoptosis
  • Apoptosis Regulatory Proteins / chemistry
  • Apoptosis Regulatory Proteins / metabolism
  • Bcl-2-Like Protein 11
  • Biphenyl Compounds / chemistry*
  • Biphenyl Compounds / metabolism*
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Mice
  • Nitrophenols / chemistry*
  • Nitrophenols / metabolism*
  • Piperazines / chemistry
  • Piperazines / metabolism
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / metabolism
  • Sulfonamides / chemistry*
  • Sulfonamides / metabolism*
  • bcl-X Protein / chemistry*
  • bcl-X Protein / metabolism*

Substances

  • ABT-737
  • Apoptosis Regulatory Proteins
  • BCL2L1 protein, human
  • BCL2L11 protein, human
  • Bcl-2-Like Protein 11
  • Bcl2l11 protein, mouse
  • Biphenyl Compounds
  • Membrane Proteins
  • Nitrophenols
  • Piperazines
  • Proto-Oncogene Proteins
  • Sulfonamides
  • bcl-X Protein