Chromatin crosstalk in development and disease: lessons from REST

Nat Rev Genet. 2007 Jul;8(7):544-54. doi: 10.1038/nrg2100.


Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression. Recent studies have shown that a single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation. Research into the function of REST and its corepressors has provided novel insight into how chromatin-modifying proteins cooperate, and how alterations in this function cause disease. These mechanisms will be relevant to the combinatorial functioning of modular transcriptional regulators that work together to regulate a common promoter; they should also identify targets for potential therapies for a range of human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Chromatin / physiology*
  • Epilepsy / genetics
  • Gene Expression Regulation*
  • Gene Silencing
  • Genes, Tumor Suppressor
  • Histones / metabolism
  • Humans
  • Molecular Sequence Data
  • RNA, Untranslated / metabolism
  • Regulon
  • Repressor Proteins / physiology*
  • Transcription Factors / physiology*


  • Chromatin
  • Histones
  • RE1-silencing transcription factor
  • RNA, Untranslated
  • Repressor Proteins
  • Transcription Factors