Neuromuscular junction in health and disease

Br J Anaesth. 2007 Jul;99(1):132-8. doi: 10.1093/bja/aem144.


A number of illnesses and other factors can affect the function of the neuromuscular junction (NMJ). These may have an affect at pre- or post-junctional sites. This review outlines the anatomy and the physiology of the NMJ. It also describes the mechanisms and physiological basis of many of the disorders of the NMJ. Finally, the importance of these disorders in anaesthetic practice is discussed.

Publication types

  • Review

MeSH terms

  • Anesthesia / methods*
  • Humans
  • Myasthenia Gravis / complications
  • Myasthenia Gravis / physiopathology
  • Neuromuscular Blocking Agents / pharmacology
  • Neuromuscular Junction / anatomy & histology
  • Neuromuscular Junction / physiology*
  • Neuromuscular Junction Diseases / complications*
  • Neuromuscular Junction Diseases / physiopathology
  • Perioperative Care / methods


  • Neuromuscular Blocking Agents