[Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy]

Arch Soc Esp Oftalmol. 2007 Jun;82(6):377-80. doi: 10.4321/s0365-66912007000600012.
[Article in Spanish]


Objective: To ascertain the efficacy of idebenone and multivitamin treatment in Leber's hereditary optic neuropathy (LHON).

Method: Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment.

Results: No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved.

Conclusions: Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Leber's disease remains to be found.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antioxidants / therapeutic use*
  • Ascorbic Acid / therapeutic use*
  • Benzoquinones / therapeutic use*
  • Female
  • Humans
  • Male
  • Optic Atrophy, Hereditary, Leber / drug therapy*
  • Riboflavin / therapeutic use*
  • Treatment Failure
  • Ubiquinone / analogs & derivatives
  • Vitamin B Complex / therapeutic use*
  • Vitamins / therapeutic use*


  • Antioxidants
  • Benzoquinones
  • Vitamins
  • Vitamin B Complex
  • Ubiquinone
  • idebenone
  • Ascorbic Acid
  • Riboflavin