Clove oil cream: a new effective treatment for chronic anal fissure

Colorectal Dis. 2007 Jul;9(6):549-52. doi: 10.1111/j.1463-1318.2006.01185.x.

Abstract

Objective: Anal fissure is a common painful condition affecting the anal canal and causes considerable morbidity and reduction in quality of life. Surgical treatment has been associated with a degree of incontinence in up to 30% of patients. This study discussed the results of clove oil 1% cream in healing of chronic anal fissure.

Method: A single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and lignocaine cream 5% against clove oil 1% cream for 6 weeks.

Results: 55 patients were included in this study, 30 patients in clove oil group and 25 patients in control group. Healing had occurred in 60% of patients in clove oil group and in 12% of patients in the control group after 3-month follow up (P < 0.001). Patients in clove oil group showed significant reduction in resting anal pressure and almost all other anorectal manometric pressures compared with patients in control group.

Conclusion: Topical application of clove oil cream demonstrated a significant beneficial effect when applied to patients suffering from chronic anal fissure.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Clove Oil / administration & dosage
  • Clove Oil / therapeutic use*
  • Fissure in Ano / drug therapy*
  • Humans
  • Middle Aged
  • Phytotherapy
  • Single-Blind Method
  • Treatment Outcome

Substances

  • Clove Oil