RNA helicases--one fold for many functions

Curr Opin Struct Biol. 2007 Jun;17(3):316-24. doi: 10.1016/j.sbi.2007.05.007. Epub 2007 Jun 15.


RNA helicases are a large group of enzymes that function in virtually all aspects of RNA metabolism. Although RNA helicases share a highly conserved structure, different enzymes display a wide array of biochemical activities, including RNA duplex unwinding, protein displacement from RNA and strand annealing. Recent structural and functional studies have started to illuminate the mechanisms by which this remarkable diversity of functions can be conducted by the conserved helicase fold.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Protein Structure, Tertiary
  • RNA / metabolism*
  • RNA Helicases / chemistry
  • RNA Helicases / physiology*


  • RNA
  • RNA Helicases