Mechanisms of obesity-associated insulin resistance: many choices on the menu

Genes Dev. 2007 Jun 15;21(12):1443-55. doi: 10.1101/gad.1550907.


Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. In the past decade, a large number of endocrine, inflammatory, neural, and cell-intrinsic pathways have been shown to be dysregulated in obesity. Although it is possible that one of these factors plays a dominant role, many of these factors are interdependent, and it is likely that their dynamic interplay underlies the pathophysiology of insulin resistance. Understanding the biology of these systems will inform the search for interventions that specifically prevent or treat insulin resistance and its associated pathologies.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Animals
  • Cardiovascular Diseases / etiology
  • Central Nervous System / physiopathology
  • Diabetes Mellitus, Type 2 / etiology
  • Fatty Acids / metabolism
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Inflammation / complications
  • Inflammation / physiopathology
  • Insulin Resistance / genetics
  • Insulin Resistance / physiology*
  • Lipid Metabolism
  • Mitochondria / metabolism
  • Models, Biological
  • Obesity / complications
  • Obesity / genetics
  • Obesity / physiopathology*
  • Oxidative Stress


  • Fatty Acids
  • Hypoglycemic Agents