PET evidence of central GABAergic changes in stiff-person syndrome

Mov Disord. 2007 May 15;22(7):1030-3. doi: 10.1002/mds.21441.

Abstract

We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Positron-Emission Tomography*
  • Stiff-Person Syndrome / diagnostic imaging*
  • Stiff-Person Syndrome / metabolism*
  • Stiff-Person Syndrome / physiopathology
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • gamma-Aminobutyric Acid