Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul;104(1):72-5. doi: 10.1016/j.tripleo.2006.07.013. Epub 2006 Oct 27.


A rare case of anaplastic ameloblastic fibrosarcoma (AS) arising in an ameloblastic fibroma (AF) of the maxilla of a 48-year-old patient 10 years after the primary excision is presented. The recurrent tumor retained focal areas of AF but manifested heterogeneous malignant features ranging from low-grade spindle to highly pleomorphic sarcomas. Biomarker analysis showed alterations of the p53 and c-KIT genes restricted to the sarcomatous component. The biological implications of these findings in the future management of these tumors are discussed.

Publication types

  • Case Reports

MeSH terms

  • Fibrosarcoma / genetics
  • Fibrosarcoma / pathology*
  • Genes, p53
  • Humans
  • Male
  • Maxillary Neoplasms / pathology*
  • Maxillary Neoplasms / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / pathology*
  • Odontoma / pathology*
  • Odontoma / surgery
  • Proto-Oncogene Proteins c-kit / genetics


  • Proto-Oncogene Proteins c-kit