Polyelectrolyte complexes based on (quaternized) poly[(2-dimethylamino)ethyl methacrylate]: behavior in contact with blood

Macromol Biosci. 2007 Jul 9;7(7):940-54. doi: 10.1002/mabi.200700056.

Abstract

Polyelectrolyte complexes (PECs) between (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and (crosslinked) N-carboxyethylchitosan (CECh) or poly(2-acrylamido-2-methylpropane sodium sulfonate) (PAMPSNa) were prepared and characterized in terms of their stability, equilibrium water content, and surface morphology. The evaluation of the behavior of the studied PECs in contact with blood revealed that the (crosslinked) CECh/(quaternized) PDMAEMA complexes had lost the inherent PDMAEMA cytotoxicity but still preserved haemostatic activity. In contrast, the complex formation between (quaternized) PDMAEMA and PAMPSNa allowed the preparation of materials with improved blood compatibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemical synthesis*
  • Blood / drug effects*
  • Blood Cell Count
  • Blood Coagulation / drug effects
  • Chitosan / analogs & derivatives
  • Chitosan / chemistry
  • Cross-Linking Reagents / chemistry
  • Drug Delivery Systems
  • Gene Transfer Techniques
  • Hemostatics
  • Humans
  • Methacrylates / chemistry*
  • Methacrylates / pharmacology
  • Methacrylates / toxicity
  • Nylons / chemistry*
  • Nylons / pharmacology
  • Nylons / toxicity
  • Polymers / chemistry
  • Sulfonic Acids / chemistry

Substances

  • Biocompatible Materials
  • Cross-Linking Reagents
  • Hemostatics
  • Methacrylates
  • N-(2-carboxyethyl)chitosan
  • Nylons
  • Polymers
  • Sulfonic Acids
  • poly(2-(dimethylamino)ethyl methacrylate)
  • poly(2-acrylamido-2-methyl-1-propanesulfonic acid)
  • Chitosan