Endosomal signaling of plant steroid receptor kinase BRI1

Genes Dev. 2007 Jul 1;21(13):1598-602. doi: 10.1101/gad.1561307. Epub 2007 Jun 19.


The LRR receptor serine/threonine kinases are a major eukaryotic receptor family, for which the central regulatory mechanism of endosomal trafficking remains largely unadressed. We show that the steroid receptor BRI1 localizes to both plasma membrane and early endosomal compartments, even when observed at low, endogenous expression levels, and that its localization and turnover are independent of ligand. However, increasing endosomal localization of BRI1 enhances activation of the pathway and genomic responses. Our data indicate distinct signaling and trafficking mechanisms within this receptor class and show that the use of endosomes as signaling compartments is an unexpectedly broad phenomenon in eukaryotes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arabidopsis / physiology*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Arabidopsis Proteins / physiology*
  • Cells, Cultured
  • Endocytosis / physiology
  • Endosomes / metabolism
  • Endosomes / physiology*
  • Green Fluorescent Proteins / genetics
  • Plant Proteins / physiology
  • Plants, Genetically Modified
  • Protein Kinases / genetics
  • Protein Kinases / metabolism
  • Protein Kinases / physiology*
  • Protein Transport / physiology
  • Signal Transduction / physiology*
  • Tissue Distribution
  • Transfection


  • Arabidopsis Proteins
  • Plant Proteins
  • Green Fluorescent Proteins
  • Protein Kinases
  • BRI1 protein, Arabidopsis