Dopa-responsive pseudo-orthostatic tremor in parkinsonism

Mov Disord. 2007 Aug 15;22(11):1652-6. doi: 10.1002/mds.21621.


In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dihydroxyphenylalanine / adverse effects*
  • Dopamine Agents / adverse effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinsonian Disorders / drug therapy
  • Parkinsonian Disorders / genetics
  • Tremor / chemically induced*
  • Tremor / classification*
  • Tremor / genetics


  • Dopamine Agents
  • Dihydroxyphenylalanine