Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis

J Rheumatol. 1991 Sep;18(9):1394-7.


The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Arthritis, Juvenile / complications*
  • Arthritis, Juvenile / genetics
  • Child
  • Child, Preschool
  • Disease Susceptibility
  • Female
  • Gene Frequency / genetics
  • Haplotypes / genetics
  • Histocompatibility Antigens Class II / genetics*
  • Histocompatibility Antigens Class II / physiology
  • Humans
  • Iridocyclitis / epidemiology*
  • Iridocyclitis / etiology
  • Iridocyclitis / genetics
  • Life Tables
  • Longitudinal Studies
  • Male
  • Risk Factors


  • Histocompatibility Antigens Class II