Membrane Protein Structure: Prediction Versus Reality

Annu Rev Biochem. 2007;76:125-40. doi: 10.1146/annurev.biochem.76.052705.163539.


Since high-resolution structural data are still scarce, different kinds of theoretical structure prediction algorithms are of major importance in membrane protein biochemistry. But how well do the current prediction methods perform? Which structural features can be predicted and which cannot? And what can we expect in the next few years?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Computational Biology
  • Membrane Proteins / chemistry*
  • Membrane Proteins / classification
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Models, Molecular*
  • Molecular Sequence Data
  • Protein Binding
  • Protein Conformation*
  • Protein Folding


  • Membrane Proteins