Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 17 (12), R478-86

Cargo Transport: Two Motors Are Sometimes Better Than One

Affiliations
Review

Cargo Transport: Two Motors Are Sometimes Better Than One

Steven P Gross et al. Curr Biol.

Abstract

Molecular motor proteins are crucial for the proper distribution of organelles and vesicles in cells. Much of our current understanding of how motors function stems from studies of single motors moving cargos in vitro. More recently, however, there has been mounting evidence that the cooperation of multiple motors in moving cargos and the regulation of motor-filament affinity could be key mechanisms that cells utilize to regulate cargo transport. Here, we review these recent advances and present a picture of how the different mechanisms of regulating the number of motors moving a cargo could facilitate cellular functions.

Similar articles

  • Bicaudal-D and Its Role in Cargo Sorting by Microtubule-Based Motors
    M Dienstbier et al. Biochem Soc Trans 37 (Pt 5), 1066-71. PMID 19754453. - Review
    Many cytoplasmic cargoes are transported along microtubules using dynein or kinesin molecular motors. As the sorting machinery of the cell needs to be tightly controlled, …
  • Molecular Motors: A Tale of Two Filaments
    SP Gross. Curr Biol 17 (8), R277-80. PMID 17437703.
    Cargos that are transported along actin frequently switch filaments. New work on single myosin V motors provides insight into this switching and its regulation, as well a …
  • Basic Mechanisms for Recognition and Transport of Synaptic Cargos
    MA Schlager et al. Mol Brain 2, 25. PMID 19653898. - Review
    Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order to transport synaptic cargo, such as synaptic vesicle precursors, mitocho …
  • Stochastic Simulations of Cargo Transport by Processive Molecular Motors
    CB Korn et al. J Chem Phys 131 (24), 245107. PMID 20059119.
    We use stochastic computer simulations to study the transport of a spherical cargo particle along a microtubule-like track on a planar substrate by several kinesin-like p …
  • Co-operative Transport by Molecular Motors
    F Berger et al. Biochem Soc Trans 39 (5), 1211-5. PMID 21936791. - Review
    Intracellular transport is often driven co-operatively by several molecular motors, which may belong to one or several motor species. Understanding how these motors inter …
See all similar articles

Cited by 72 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback