Abstract
Twenty nine skunks (Mephitis mephitis) were vaccinated orally with raccoon poxvirus (RCN) recombinants: 10 with a recombinant expressing the rabies virus glycoprotein (RCNRG), 10 with RCNRG mixed with a recombinant expressing the rabies virus nucleoprotein (RCNRN) and nine with RCN alone. Rabies virus neutralizing antibodies were detected in six of the 20 skunks; five skunks (three given RCNRG, two given a mixture of recombinants) survived a rabies challenge that was lethal for nine skunks vaccinated with RCN alone.
MeSH terms
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Administration, Oral
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Animals
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Antibodies, Viral / biosynthesis*
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Gene Expression Regulation, Viral
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Glycoproteins / immunology
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Mephitidae*
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Nucleoproteins / immunology
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Poxviridae / genetics
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Poxviridae / immunology
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Rabies / prevention & control
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Rabies / veterinary*
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Rabies Vaccines* / administration & dosage
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Rabies Vaccines* / immunology
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Rabies virus / immunology*
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Raccoons
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / immunology
Substances
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Antibodies, Viral
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Glycoproteins
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Nucleoproteins
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Rabies Vaccines
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Vaccines, Synthetic