Prosthodontic treatment in patients with ectodermal dysplasia (ED) is difficult to manage because of the oral deficiencies typical in this disorder and because afflicted individuals are quite young when they are evaluated for treatment. This clinical report describes an 18-year-old patient with hypohidrotic ED treated with dental implants. Treatment included a maxillary implant overdenture and a mandibular hybrid prosthesis supported by osseointegrated implants. At the one-year follow-up, the patient presented significant improvements in oral function and psychosocial activities.