Base-excision repair of oxidative DNA damage

Nature. 2007 Jun 21;447(7147):941-50. doi: 10.1038/nature05978.


Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / metabolism
  • DNA Damage*
  • DNA Glycosylases / metabolism
  • DNA Repair*
  • DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism
  • Guanine / analogs & derivatives*
  • Guanine / metabolism
  • Humans


  • 8-hydroxyguanine
  • Guanine
  • DNA Glycosylases
  • mutY adenine glycosylase
  • DNA-(Apurinic or Apyrimidinic Site) Lyase