Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from

Immunity. 2007 Jun;26(6):678-89. doi: 10.1016/j.immuni.2007.05.009.


T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Bone Marrow / immunology
  • Bone Marrow Transplantation
  • Cell Lineage*
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • T-Lymphocytes / immunology*
  • Thymus Gland / cytology
  • Thymus Gland / immunology*