Abstract
The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Benzoquinones / administration & dosage
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Benzoquinones / pharmacology*
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Benzoquinones / therapeutic use
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Cells, Cultured
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Glycation End Products, Advanced / metabolism
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Humans
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Interleukin-6 / metabolism
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Kidney Tubules / cytology
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Kidney Tubules / drug effects*
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Kidney Tubules / metabolism
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NF-kappa B / metabolism
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Nigella sativa*
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Phytotherapy*
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Plant Oils / administration & dosage
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Plant Oils / pharmacology*
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Plant Oils / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Benzoquinones
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Glycation End Products, Advanced
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Interleukin-6
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NF-kappa B
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Plant Oils
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thymoquinone