Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells

Phytother Res. 2007 Sep;21(9):898-9. doi: 10.1002/ptr.2177.

Abstract

The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Benzoquinones / administration & dosage
  • Benzoquinones / pharmacology*
  • Benzoquinones / therapeutic use
  • Cells, Cultured
  • Glycation End Products, Advanced / metabolism
  • Humans
  • Interleukin-6 / metabolism
  • Kidney Tubules / cytology
  • Kidney Tubules / drug effects*
  • Kidney Tubules / metabolism
  • NF-kappa B / metabolism
  • Nigella sativa*
  • Phytotherapy*
  • Plant Oils / administration & dosage
  • Plant Oils / pharmacology*
  • Plant Oils / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzoquinones
  • Glycation End Products, Advanced
  • Interleukin-6
  • NF-kappa B
  • Plant Oils
  • thymoquinone