Power in Voxel-based lesion-symptom mapping

J Cogn Neurosci. 2007 Jul;19(7):1067-80. doi: 10.1162/jocn.2007.19.7.1067.


Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxel-based approaches to mapping lesion-behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize the use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain Injuries / pathology*
  • Brain Injuries / physiopathology*
  • Brain Mapping*
  • Cerebral Cortex / pathology
  • Databases, Factual / statistics & numerical data
  • Functional Laterality / physiology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Signal Processing, Computer-Assisted*
  • Statistics as Topic