Allosteric enhancers for A1 adenosine receptor

Mini Rev Med Chem. 2007 Jun;7(6):559-69. doi: 10.2174/138955707780859459.


Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.

Publication types

  • Review

MeSH terms

  • Adenosine A1 Receptor Agonists*
  • Animals
  • Cyclic AMP / metabolism
  • Humans
  • Molecular Conformation
  • Receptor, Adenosine A1 / chemistry*
  • Structure-Activity Relationship


  • Adenosine A1 Receptor Agonists
  • Receptor, Adenosine A1
  • Cyclic AMP