Endothelial signaling by Ig-like cell adhesion molecules

Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):1870-6. doi: 10.1161/ATVBAHA.107.145821. Epub 2007 Jun 21.


The migration of leukocytes across the endothelial lining of the vascular wall requires a complicated series of adhesion and signaling events. Endothelial Ig-like cell adhesion molecules (IgCAMs) such as intercellular adhesion molecule-1 play an important role, not only as ligands for leukocyte integrins, but also as signaling initiators. Clustering these IgCAMs triggers a wide range of events in the endothelial cells' interior, of which activation of Rho-like GTPases, induction of cytoskeletal changes, and the transient modulation of cell-cell contact are key events. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, CD / physiology
  • Cell Adhesion Molecules / physiology
  • Chemotaxis, Leukocyte / physiology*
  • Endothelial Cells / physiology*
  • Humans
  • Intercellular Adhesion Molecule-1 / physiology
  • Leukocytes / physiology
  • Signal Transduction / physiology*
  • Vascular Cell Adhesion Molecule-1 / physiology
  • rho GTP-Binding Proteins / physiology


  • Antigens, CD
  • Cell Adhesion Molecules
  • ICAM2 protein, human
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • rho GTP-Binding Proteins