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, 9 (15), 2783-6

Samarium Triflate-Catalyzed Halogen-Promoted Friedel-Crafts Alkylation With Alkenes

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Samarium Triflate-Catalyzed Halogen-Promoted Friedel-Crafts Alkylation With Alkenes

Saumen Hajra et al. Org Lett.

Abstract

A versatile and efficient halogen-promoted highly regio- and stereoselective Friedel-Crafts (F-C) alkylation with alkenes has been developed with use of easily available and inexpensive NBS or I2 as the efficient halogen sources. Lewis acids, in particular metal triflates, are found to be effective catalysts for this halogen-promoted F-C alkylation. Among these, Sm(OTf)3 was the best catalyst. Electron-rich arenes smoothly underwent F-C alkylation with a variety of alkenes including alpha,beta-unsaturated carbonyl compounds.

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