Tyrosine supplementation mitigates working memory decrements during cold exposure

Physiol Behav. 2007 Nov 23;92(4):575-82. doi: 10.1016/j.physbeh.2007.05.003. Epub 2007 May 22.


In rats, dietary supplementation with the amino acid tyrosine (TYR) prevents depletion of central catecholamines observed during acute environmental stress. Concomitant changes in the animals' behavioral responses to stress suggest that TYR might have similar effects on central catecholamines and cognition in humans exposed to environmental stress. This study aimed to determine if severe cold exposure impairs human cognition and if dietary supplementation with TYR would ameliorate such deficits. Volunteers (N=19) completed three test sessions on different days (35 degrees C control/placebo, approximately 10 degrees C/placebo, approximately 10 degrees C/TYR) using a double-blind, within subjects design. During each session, volunteers completed two 90-minute water immersions and consumed a food bar (150 mg/kg TYR or placebo) before each immersion (total TYR 300 mg/kg). Cognitive performance, mood, and salivary cortisol were assessed. Cortisol was elevated in the cold (p<.01). Volunteers made fewer correct responses on a Match-to-Sample memory measure (p<.05) and reaction time (RT) and errors increased on a choice RT test (p<.01) in the cold. Self-reported tension (p<.01), depression (p<.05) and confusion (p<.01) also increased in the cold. When volunteers consumed TYR, correct responses increased on a Match-to-Sample memory measure (p<.05) and study time for the sample was shorter (p<.05), indicative of more rapid and accurate information processing. Finally, RT on the memory measure revealed a similar pattern across immersions for TYR and thermoneutral conditions, but not cold/placebo (p<.05). This study demonstrates cold exposure degrades cognitive performance and supplementation with TYR alleviates working memory decrements.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adaptation, Physiological / drug effects
  • Adolescent
  • Adult
  • Analysis of Variance
  • Body Temperature
  • Cognition / drug effects*
  • Cognition / physiology
  • Cold Temperature
  • Dietary Supplements
  • Discrimination Learning / drug effects
  • Discrimination Learning / physiology
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Memory, Short-Term / drug effects*
  • Memory, Short-Term / physiology
  • Reaction Time / drug effects*
  • Reaction Time / physiology
  • Reference Values
  • Stress, Physiological / metabolism*
  • Tyrosine / metabolism*
  • Tyrosine / pharmacology


  • Tyrosine