Bacteria interfere with A. actinomycetemcomitans colonization

J Dent Res. 2007 Jul;86(7):611-7. doi: 10.1177/154405910708600706.


It is known that beneficial bacteria can suppress the emergence of pathogenic bacteria, particularly in the gastrointestinal tract. This study examined the potential for a similar suppression of Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans colonization of epithelial cells, due to its potential relevance in periodontal diseases. Seven presumed beneficial bacteria were examined for their ability to interfere, exclude, or displace A. actinomycetemcomitans from epithelial cells in vitro. Streptococcus sanguinis, Streptococcus mitis, and Streptococcus salivarius showed prominent inhibitory effects on either A. actinomycetemcomitans recovery or colonization. These results confirmed the hypothesis that bacterial interactions interfere with A. actinomycetemcomitans colonization of epithelial cells in vitro, and demonstrated the potential beneficial effects of S. mitis, S. salivarius, and S. sanguinis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aggregatibacter actinomycetemcomitans / physiology*
  • Antibiosis / physiology*
  • Bacterial Adhesion
  • Binding, Competitive
  • Colony Count, Microbial
  • Epithelial Cells / microbiology*
  • HeLa Cells
  • Humans
  • Streptococcus / physiology*
  • Streptococcus mitis / physiology
  • Streptococcus sanguis / physiology