Familial ankyloglossia (tongue-tie)

Int J Pediatr Otorhinolaryngol. 2007 Aug;71(8):1321-4. doi: 10.1016/j.ijporl.2007.05.018. Epub 2007 Jun 22.


Ankyloglossia (tongue-tie) is a congenital anomaly with a prevalence of 4-5% and characterized by an abnormally short lingual frenulum. For unknown reasons the abnormality seems to be more common in males. The pathogenesis of ankyloglossia is not known. The author reports a family with isolated ankyloglossia inherited as an autosomal dominant trait. The identification of the defective gene(s) causing ankyloglossia might reveal novel information on the craniofacial embryogenesis and its disorders.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Lingual Frenum / abnormalities*
  • Lingual Frenum / surgery*
  • Pedigree
  • Tongue Diseases / genetics*