Life and death in peripheral T cells

Nat Rev Immunol. 2007 Jul;7(7):532-42. doi: 10.1038/nri2115.


During the course of an immune response, antigen-reactive T cells clonally expand and then are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is determined by multiple factors, such as T-cell receptor triggering, co-stimulation or cytokine signalling, and by molecules, such as caspase-8 (FLICE)-like inhibitory protein (FLIP) and haematopoietic progenitor kinase 1 (HPK1), which regulate the nuclear factor-kappaB (NF-kappaB) pathway. Here, we discuss the concepts of activation-induced cell death (AICD) and activated cell-autonomous death (ACAD) in the regulation of life and death in T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology*
  • Cell Proliferation
  • Cell Survival
  • Down-Regulation
  • Humans
  • Signal Transduction / immunology
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology*