Localized conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is amenable to local chemotherapy

Int Ophthalmol. 2008 Feb;28(1):51-4. doi: 10.1007/s10792-007-9102-5. Epub 2007 Jun 23.


Purpose: Conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is a rare, low-grade, non-Hodgkin's B-cell lymphoma. We report our successful management of localized conjunctival MALT lymphoma with topical Mitomycin C (MMC).

Methods: This is a case report. A 35-year-old woman had a mobile painless 1.5x1-cm mass in the left conjunctiva for 2 years. Examination revealed two similar masses in the right conjunctiva. Incisional biopsy for immunohistochemical stain and PCR of the left conjunctival mass showed MALT lymphoma. She was given four courses of topical 0.04% MMC eyedrops. There was transient conjunctival injection and superficial punctate keratopathy which responded to topical steroid and lubricant.

Results: The lesions regressed completely after the fourth cycle of treatment and repeat biopsy confirmed complete remission.

Conclusion: This is the first report of localized conjunctival MALT lymphoma being successfully treated by topical MMC with minimal local controllable side effects.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adult
  • Antibiotics, Antineoplastic / administration & dosage*
  • Biopsy
  • Conjunctival Neoplasms / drug therapy*
  • Conjunctival Neoplasms / pathology
  • Female
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / drug therapy*
  • Lymphoma, B-Cell, Marginal Zone / pathology
  • Mitomycin / administration & dosage*
  • Polymerase Chain Reaction


  • Antibiotics, Antineoplastic
  • Mitomycin