Inhibition of beta-amyloid aggregation and neurotoxicity by complementary (antisense) peptides

Chembiochem. 2002 Jan 4;3(1):86-92. doi: 10.1002/1439-7633(20020104)3:1<86::AID-CBIC86>3.0.CO;2-L.


Complementary peptides are coded for by the nucleotide sequence (read 5'-->3') of the complementary strand of DNA. By reading the sequence of complementary DNA in the 3'-->5' direction, alternative complementary peptides may be derived. We describe the derivation, testing and analysis of six complementary peptides designed against beta-amyloid peptide 1-40 (Abeta, 40). Data is presented to show that one peptide, designated 3' -->5' betaCP1-15, binds specifically to Abeta 1-40, and inhibits both fibrilisation and neurotoxicity in vitro. This suggests that complementary peptides could be useful leads for drug discovery, especially where diseases of protein misfolding are concerned.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / toxicity*
  • Antisense Elements (Genetics) / chemistry
  • Antisense Elements (Genetics) / pharmacology*
  • Biosensing Techniques
  • Cell Line
  • DNA / chemistry
  • DNA / drug effects
  • Humans
  • Kinetics
  • Molecular Sequence Data
  • Neurotoxins / toxicity


  • Amyloid beta-Peptides
  • Antisense Elements (Genetics)
  • Neurotoxins
  • DNA