Abstract
A series of the most common chelators used in magnetic resonance imaging (MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X-ray structures and theoretical studies.
MeSH terms
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Chelating Agents / chemistry*
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Chelating Agents / therapeutic use
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Cyclams
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Heterocyclic Compounds / chemistry*
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Humans
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Lanthanoid Series Elements / chemistry
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Molecular Structure
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Neoplasms / diagnostic imaging
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Neoplasms / radiotherapy
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Organometallic Compounds / chemistry*
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Organometallic Compounds / therapeutic use
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Radionuclide Imaging
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Radiopharmaceuticals / chemistry*
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Radiopharmaceuticals / therapeutic use
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Thermodynamics
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Transition Elements / chemistry*
Substances
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Chelating Agents
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Cyclams
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Heterocyclic Compounds
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Lanthanoid Series Elements
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Organometallic Compounds
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Radiopharmaceuticals
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Transition Elements
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cyclam
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cyclen