Growth factors in ovarian development

Semin Reprod Med. 2007 Jul;25(4):225-34. doi: 10.1055/s-2007-980216.


Folliculogenesis in the adult ovary proceeds from quiescent primordial follicles through several developmental stages that culminate in the release of oocytes for fertilization and terminal differentiation of follicles into corpora lutea. Multiple developmental pathways control growth of oocytes and differentiation of somatic cells of the follicle. Growth factors of the transforming growth factor beta family play prominent roles during follicle development. Recent studies have begun to examine the role of additional developmentally important growth factor families, such as the Hedgehog, Wnt, and Notch families. This review summarizes recent developments on these signaling pathways in the adult mammalian ovary.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Egg Proteins / metabolism*
  • Female
  • Fertility / physiology
  • Hedgehog Proteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Oogenesis / physiology
  • Ovarian Follicle / cytology
  • Ovarian Follicle / metabolism
  • Ovary / growth & development*
  • Ovary / metabolism
  • Reproduction / physiology*
  • Signal Transduction*
  • Transforming Growth Factor beta / metabolism
  • Wnt Proteins / metabolism


  • Egg Proteins
  • Hedgehog Proteins
  • Intracellular Signaling Peptides and Proteins
  • Transforming Growth Factor beta
  • Wnt Proteins