Comparative profile analysis of cognitive function in recent-onset and chronic patients with adolescent-onset schizophrenia

Schizophr Res. 2007 Aug;94(1-3):240-4. doi: 10.1016/j.schres.2007.05.014. Epub 2007 Jun 26.


We used z-transformed scores derived with reference to 43 healthy controls to compare cognitive profiles and selectivity of cognitive deficits in 19 recent-onset and 23 chronic patients with adolescent-onset schizophrenia. Relative to the controls, both patient groups were impaired in IQ, verbal memory and planning, but not visual memory or attention/mental flexibility. There were no significant differences in level or shape of cognitive profile between the two patient groups. Attention/mental flexibility emerged as a selective strength, and planning as a selective deficit, while verbal memory showed a trend towards selective impairment in the patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age of Onset
  • Cognition Disorders / diagnosis
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / etiology*
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Schizophrenia / complications*
  • Schizophrenia / epidemiology*