Randomized controlled trial of light-emitting diode phototherapy

J Perinatol. 2007 Sep;27(9):565-7. doi: 10.1038/sj.jp.7211789. Epub 2007 Jun 28.


Objective: We wished to compare the efficacy of light-emitting diode (LED) phototherapy with special blue fluorescent (BB) tube phototherapy in the treatment of neonatal hyperbilirubinemia.

Study design: We randomly assigned 66 infants >or=35 weeks of gestation to receive phototherapy using an LED device or BB. In addition to phototherapy from above, all infants also received phototherapy from below using four BB tubes or a fiberoptic pad.

Result: After 15+/-5 h of phototherapy, the rate of decline in the total serum bilirubin (TSB) was 0.35+/-0.25 mg/dl/h in the LED group vs 0.27+/-0.25 mg/dl/h in the BB group (P=0.20).

Conclusion: LED phototherapy is as effective as BB phototherapy in lowering serum bilirubin levels in term and near-term newborns.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bilirubin / blood
  • Female
  • Fiber Optic Technology
  • Gestational Age
  • Humans
  • Hyperbilirubinemia, Neonatal / blood
  • Hyperbilirubinemia, Neonatal / therapy*
  • Infant, Newborn
  • Male
  • Phototherapy / instrumentation*
  • Phototherapy / methods
  • Treatment Outcome


  • Bilirubin