The current study examines communication about sex-related topics with close friends and mothers during the first semester of college. Students (N = 182, 50% female, mean age = 18.5) completed surveys about the frequency and quality of their sex-related communication with same-sex close friends and mothers, and sexual experience and attitudes. Sex-related communication was more frequently reported by women than men and with close friends than with mothers. Sexually active students discussed most topics more frequently than abstinent students. Communication with close friends was a stronger correlate of sexual attitudes than communication with mothers. Finally, the quality of communication with close friends was more strongly associated with sexual experience and attitudes than communication with mothers. Findings suggest the importance of understanding the role of friends in assigning meaning to sexual behaviors and beliefs.