Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years

Am J Cardiol. 2007 Jul 1;100(1):115-21. doi: 10.1016/j.amjcard.2007.02.065. Epub 2007 May 24.


The role of uric acid (UA) in the process of atherothrombosis is controversial. Although serum UA has powerful antioxidant properties, epidemiological studies showed that UA was a risk factor for cardiovascular diseases and was positively associated with proinflammatory markers. Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Subjects had complete baseline and follow-up data for UA, inflammatory markers, and covariates. An autoregressive approach was used to study such a relation. In adjusted analyses, baseline UA and changes in UA predicted a 3-year change in CRP (p = 0.028), but not IL-6 (p = 0.101). The relation between UA and CRP persisted after adjustment for baseline IL-6. Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Atherosclerosis / blood
  • Atherosclerosis / etiology
  • C-Reactive Protein / analysis*
  • Cardiovascular Diseases / blood*
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Interleukin-6 / blood*
  • Italy
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Thrombosis / blood
  • Thrombosis / etiology
  • Time Factors
  • Uric Acid / blood*


  • Interleukin-6
  • Uric Acid
  • C-Reactive Protein