[Contemporary molecular-biological methods of cancer diagnosis and monitoring based on the humoral immune response to tumor-associated antigens]

Mol Gen Mikrobiol Virusol. 2007:(2):3-6.
[Article in Russian]


Humoral immune response to tumor-associated antigens in cancer patients can be used as a basis for disease diagnosis and monitoring. Moreover, identification of molecular targets of such response may be used to develop antigen-specific anticancer vaccines. Here, we review the main approaches to identification and study of tumor-associated antigens recognized by serum antibodies. We also focus on the challenges that must be met before serological antigens can be used in clinical cancer diagnostics.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Neoplasm / immunology*
  • Antibody Formation*
  • Antigens, Neoplasm / immunology*
  • Diagnosis, Differential
  • Humans
  • Monitoring, Physiologic
  • Neoplasms / diagnosis*
  • Neoplasms / immunology*


  • Antibodies, Neoplasm
  • Antigens, Neoplasm