High incidence of autoimmune disease in Japanese patients with ocular adnexal reactive lymphoid hyperplasia

Am J Ophthalmol. 2007 Jul;144(1):148-9. doi: 10.1016/j.ajo.2007.03.018.


Purpose: To determine the incidence of autoimmune disease in Japanese patients with ocular adnexal lymphoid proliferations.

Design: Case series study.

Methods: The authors investigated the incidence of autoimmune disease in 88 patients with primary ocular adnexal lymphoid proliferations. Southern blot analysis was used to determine the presence of B-cell clonality in reactive lymphoid hyperplasia (RLH) associated with autoimmune disease.

Results: Histopathologic analysis indicated that 15 (17%) patients had RLH, 62 (70%) patients had mucosa-associated lymphoid tissue lymphoma (MALToma), and 11 (13%) patients had primary lymphomas. The incidence of autoimmune disease was seven (47%) of 15 patients with RLH, two (3%) of 62 patients with MALToma, and zero (0%) of 11 patients with primary lymphoma. B-cell clonality was detected in one (14%) of seven RLH patients with autoimmune disease.

Conclusions: Ocular adnexal RLH with or without B-cell clonality is highly associated with autoimmune disease.

MeSH terms

  • Adult
  • Aged
  • Autoimmune Diseases / epidemiology*
  • Blotting, Southern
  • Eye Diseases / epidemiology
  • Eye Neoplasms / epidemiology*
  • Female
  • Humans
  • Incidence
  • Japan / epidemiology
  • Lacrimal Apparatus Diseases / epidemiology
  • Lymphoma / epidemiology*
  • Lymphoma, B-Cell, Marginal Zone / epidemiology*
  • Male
  • Middle Aged
  • Pseudolymphoma / epidemiology*
  • Sjogren's Syndrome / epidemiology