Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies
- PMID: 17601626
- DOI: 10.1016/j.diabres.2007.05.004
Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies
Abstract
Background: Several estimates of the risk of progression to diabetes in people with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) have been reported.
Objective: To provide an estimate of the risk of progression to diabetes and regression to normoglycemia in these populations.
Design: Systematic overview and meta-analysis of prospective cohort studies published from 1979 until 2004.
Setting: Global cohort studies.
Patients: People with IFG or IGT detected by a screening oral glucose tolerance test.
Measurements: Fasting and post-load plasma glucose levels.
Results: The absolute annual incidence of diabetes in individuals with various categories of IFG or IGT varied from 5 to 10%. Compared to normoglycemic people the meta-analyzed relative risk and 95% confidence interval for diabetes was: 6.35 (4.87-7.82) in people with IGT; 5.52 (3.13-7.91) in people with isolated IGT; 4.66 (2.47-6.85) in people with IFG; 7.54 (4.63-10.45) in people with isolated IFG; and 12.13 (4.27-20.00) in people with both IFG and IGT. People with IGT were 0.33 times as likely to be normoglycemic after 1 year compared to people with normal glucose tolerance (95% CI 0.23-0.43).
Limitations: Studies that used differing criteria for IFG and IGT were included, and participants were classified on the basis of only one test.
Conclusion: IFG and IGT are associated with similar, high relative risk for incident diabetes. The combined abnormality of IFG plus IGT is associated with the highest relative risk.
Similar articles
-
High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study.BMC Public Health. 2008 May 24;8:176. doi: 10.1186/1471-2458-8-176. BMC Public Health. 2008. PMID: 18501007 Free PMC article.
-
Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study.Diabetes Care. 2008 Feb;31(2):267-72. doi: 10.2337/dc07-0912. Epub 2007 Nov 5. Diabetes Care. 2008. PMID: 17989310
-
Progression to impaired glucose metabolism in first-degree relatives of patients with type 2 diabetes in Isfahan, Iran.Diabetes Metab Res Rev. 2009 Nov;25(8):748-55. doi: 10.1002/dmrr.1038. Diabetes Metab Res Rev. 2009. PMID: 19862775
-
Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health Study.Diabetes Care. 2008 May;31(5):1001-6. doi: 10.2337/dc07-2003. Epub 2008 Feb 11. Diabetes Care. 2008. PMID: 18268072
-
Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study.Diabetes Care. 2007 Feb;30(2):325-31. doi: 10.2337/dc06-1457. Diabetes Care. 2007. PMID: 17259502
Cited by
-
Evaluating the Implementation of a Digital Diabetes Prevention Program in an Integrated Health Care Delivery System Among Older Adults: Results of a Natural Experiment.Clin Diabetes. 2022 Summer;40(3):345-353. doi: 10.2337/cd21-0114. Clin Diabetes. 2022. PMID: 35983414
-
High Serum FABP4 Levels are Negatively Associated with the Reversion from Prediabetes to Normal Glucose Tolerance: A 2-Year Retrospective Cohort Community Study.Diabetes Metab Syndr Obes. 2022 Jul 28;15:2217-2225. doi: 10.2147/DMSO.S374912. eCollection 2022. Diabetes Metab Syndr Obes. 2022. PMID: 35923252 Free PMC article.
-
Glucometabolic State Transitions: The Jackson Heart Study.Ethn Dis. 2022 Jul 21;32(3):203-212. doi: 10.18865/ed.32.3.203. eCollection 2022 Summer. Ethn Dis. 2022. PMID: 35909644
-
Predictive Efficiency of Prediabetes for Diabetes Among Chinese Middle-Aged and Older Populations: a 5-Year National Prospective Cohort Study.J Gen Intern Med. 2022 Jul 11. doi: 10.1007/s11606-022-07731-x. Online ahead of print. J Gen Intern Med. 2022. PMID: 35819686
-
Evaluating the Implementation of Digital and In-Person Diabetes Prevention Program in a Large, Integrated Health System: Natural Experiment Study Design.Perm J. 2021 Dec 13;26(1):21-31. doi: 10.7812/TPP/21.056. Perm J. 2021. PMID: 35609151 Free PMC article.
Publication types
MeSH terms
Substances
Grant support
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
