Long-term use of nebulized human recombinant DNase1 in two siblings with primary ciliary dyskinesia

Respir Med. 2007 Oct;101(10):2224-6. doi: 10.1016/j.rmed.2007.05.014. Epub 2007 Jun 29.


Primary ciliary dyskinesia (PCD) is characterized by ultra-structural defects of the cilia. In this report, we describe the long-term use of nebulized dornase alfa in two siblings with PCD. This is the first report of long-term use of dornase alfa in PCD.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Deoxyribonuclease I / administration & dosage*
  • Forced Expiratory Volume / drug effects
  • Humans
  • Kartagener Syndrome / drug therapy*
  • Long-Term Care / methods
  • Male
  • Nebulizers and Vaporizers
  • Treatment Outcome


  • DNASE1 protein, human
  • Deoxyribonuclease I