Cucurbitane glycosides from unripe fruits of Siraitia grosvenori

Chem Pharm Bull (Tokyo). 2007 Jul;55(7):1082-6. doi: 10.1248/cpb.55.1082.


Studies on the constituents of the unripe fruits of Siraitia grosvenori led to the isolation of three new cucurbitane triterpene glycosides, 11-oxomogroside III (10), 11-dehydroxymogroside III (11), and 11-oxomogroside IV A (12). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods. All of the compounds isolated from the unripe fruits of S. grosvenori were tested for cytotoxic activities against tumor cells, HCT-116 and SMMC-7721.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cucurbitaceae*
  • Fruit / chemistry*
  • Glycosides / chemistry*
  • Glycosides / pharmacology
  • Humans
  • Molecular Structure


  • 11-dehydroxymogroside III
  • 11-oxomogroside III
  • 11-oxomogroside IV A
  • Glycosides