Irreversible cell-cycle transitions are due to systems-level feedback

Nat Cell Biol. 2007 Jul;9(7):724-8. doi: 10.1038/ncb0707-724.


The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / physiology*
  • Cell Division / physiology
  • DNA Replication
  • Feedback, Physiological
  • Humans
  • Models, Biological*


  • Cell Cycle Proteins