T1 and T2 relaxation times in schizophrenia as measured with magnetic resonance imaging

Schizophr Res. 1991 Oct;5(3):223-32. doi: 10.1016/0920-9964(91)90080-b.


T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the right hemisphere and in gray matter structures. These results may indicate that metabolic, physiological, or neurochemical brain function in schizophrenia is related in some way to a change in tissue fluid in neuronal cell bodies or interstitial gray matter.

MeSH terms

  • Adult
  • Brain / pathology*
  • Brain Mapping
  • Dominance, Cerebral / physiology
  • Extracellular Space / physiology
  • Female
  • Humans
  • Intracellular Fluid / physiology
  • Magnetic Resonance Imaging*
  • Male
  • Neurocognitive Disorders / diagnosis
  • Neurocognitive Disorders / pathology*
  • Neurocognitive Disorders / psychology*
  • Schizophrenia / diagnosis
  • Schizophrenia / pathology*
  • Schizophrenic Psychology*