Origin of ganglioside complex antibodies in Guillain-Barré syndrome

J Neuroimmunol. 2007 Aug;188(1-2):69-73. doi: 10.1016/j.jneuroim.2007.05.014. Epub 2007 Jun 29.


The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies / blood*
  • Campylobacter jejuni / immunology*
  • Campylobacter jejuni / metabolism
  • Gangliosides / immunology*
  • Guillain-Barre Syndrome / blood
  • Guillain-Barre Syndrome / immunology*
  • Humans
  • Male
  • Middle Aged


  • Antibodies
  • Gangliosides