Emerging drugs for hepatitis B

Expert Opin Emerg Drugs. 2007 May;12(2):199-217. doi: 10.1517/14728214.12.2.199.

Abstract

Chronic hepatitis B remains a treatment challenge despite the availability of new nucleoside analogs. This is due to the persistence of viral infection during therapy, which exposes the patient to the risk of developing antiviral drug resistance. Therefore, new polymerase inhibitors are needed to manage resistance to existing drugs and new trials of combination therapy are required to delay drug resistance. In the future, antiviral agents targeting other steps of the viral life cycle will be needed to achieve antiviral synergy and prevent antiviral drug resistance. Immune modulators are also expected to enhance antiviral response and to achieve sustained response. Discovery of new antiviral drugs and design of new treatment strategies are, therefore, needed to manage this disease, which is still the main cause of cirrhosis and hepatocellular carcinoma worldwide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Drug Resistance, Viral / drug effects
  • Drug Resistance, Viral / physiology
  • Hepatitis B / drug therapy*
  • Hepatitis B / metabolism
  • Hepatitis B / virology
  • Hepatitis B virus / drug effects
  • Hepatitis B virus / metabolism
  • Hepatitis B, Chronic / drug therapy
  • Hepatitis B, Chronic / metabolism
  • Hepatitis B, Chronic / virology
  • Humans

Substances

  • Antiviral Agents