The X factor: skewing X inactivation towards cancer

Cell. 2007 Jun 29;129(7):1253-4. doi: 10.1016/j.cell.2007.06.008.

Abstract

Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / genetics
  • Cell Transformation, Neoplastic / genetics*
  • Chromosomes, Human, X / genetics*
  • Forkhead Transcription Factors / genetics*
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Mutation / genetics
  • Receptor, ErbB-2 / genetics*
  • Tumor Suppressor Proteins / genetics*
  • X Chromosome Inactivation / genetics*

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Tumor Suppressor Proteins
  • Receptor, ErbB-2