Serum levels of OPG, RANKL and RANKL/OPG ratio in newly-diagnosed patients with multiple myeloma. Clinical correlations

Haematologica. 2007 Jul;92(7):1000-1. doi: 10.3324/haematol.10943.


Serum levels of OPG and RANKL and their clinical correlations were analyzed in 66 newly-diagnosed patients with multiple myeloma (MM). RANKL and RANKL /OPG ratio were significantly increased in advanced clinical stages and high grade myeloma bone disease (MBD), while OPG showed a tendency to decrease. Renal failure modified the expression of OPG. RANKL and RANKL/OPG ratios are informative markers for myeloma tumor burden and MBD.

MeSH terms

  • Biomarkers / blood
  • Bone Neoplasms / diagnosis
  • Humans
  • Multiple Myeloma / complications
  • Multiple Myeloma / diagnosis*
  • Osteoprotegerin / blood*
  • RANK Ligand / blood*
  • Renal Insufficiency / diagnosis
  • Tumor Burden


  • Biomarkers
  • Osteoprotegerin
  • RANK Ligand